March 24, 2022

CyberKnife Robotic Radiosurgery System

The CyberKnife is a dedicated stereotactic radiosurgery and stereotactic radiotherapy system which is distinguished for its innovative design and ground-breaking technology. It was the first system to obviate the need for a mechanical fixation frame for intracranial treatments by utilizing real time image-guided technology coupled with a robotic manipulator. With CyberKnife, radiosurgery can be applied for the treatment of lesions (malignant, benign, or functional) anywhere in the body upon clinical indication.  

What are the advantages of CyberKnife? 

  • Using a dedicated image-guided system and artificial intelligence, the system can detect patient movements and adjust accordingly the therapeutic beam to maintain delivery accuracy. Removal of the skull mechanical fixation enabled the delivery of radiosurgery treatments not only in the brain but anywhere in the body.  
  • Larger lesions can be treated with hypofractionation schemes. The use of image guidance enabled the treatment of larger lesions or lesions adjacent to sensitive structures, in more than one fraction and up to five fractions.  
  • Precise targeting (within 1 mm) of the lesion, irrespective of the treated body anatomy. The achieved sub-millimetric accuracy helps to significantly reduce side effects and assure an increased quality of life of the patient.  
  • Delivery of dose distributions that conform with the target shape. The system uses multiple non-coplanar with different shape beams to create dose distributions that conform with the shape of the treated lesion and at the same time have an increase spatial dose gradient to minimize irradiation of the surrounded healthy tissue.  
  • Treatment of lesions that move with respiration. The CyberKnife uses the SynchronyTM system to synchronize the position of each beam with the target, as the patient breathes normally on the treatment couch. With this technology, lesions in the lung, liver, kidney, and pancreas that move with respiration can be treated with increased accuracy and minimal side effects.  
  • Treatment is pain free and doesn’t require anesthesia. Patients can continue normal activity straight after treatment.  

Conditions treated with CyberKnife 

Central nervous system (Brain and spinal cord):  

  • Meningiomas, 
  • Acoustic Schwannomas 
  • Pituitary adenomas  
  • Arteriovenous Malformations 
  • Metastases 
  • Glioma relapses after radiotherapy  
  • Functional lesions (e.g., trigeminal neuralgia) 


Spine metastases  


  • Stage I or II non-small cell lung cancer (NSCLC) 
  • Local relapse of NSCLC, after radiotherapy 
  • Solitary pulmonary metastasis 


  • Hepatocellular cancer 
  • Cholangiocarcinoma 
  • Hepatic metastases 


  • Adenocarcinoma: 
    -for local disease, as monotherapy or in combination 
    -for disseminated disease (combined with chemo or radiotherapy) 


  • Early-stage prostate adenocarcinomas (T1 or T2a)