Ovarian Rejuvenation: Scientific Approach and Success in Angeliki’s Case
The case of Angeliki, a 46-year-old woman, serves as a remarkable example in the field of reproductive medicine. Despite significant challenges due to perimenopause and three unsuccessful attempts of in vitro fertilization (IVF), she successfully gave birth to a healthy baby boy with her own eggs. This achievement is not only a personal triumph but also a promising indication for the scientific community and for women facing similar fertility issues.
The medical approach used in her case was ovarian rejuvenation through the injection of PRP (platelet-rich plasma) by laparoscopy. PRP consists of plasma derived from the patient’s own blood, which is then injected directly into the ovaries. The goal of this procedure is to regenerate ovarian tissue and improve ovarian function, thereby increasing the possibility of natural conception. Although still at an experimental stage, this method has shown promising results in several cases.
Despite having pathological high levels of key hormones such as FSH and very low levels of AMH and estradiol—typically indicators of diminished ovarian function—Angeliki was ultimately able to conceive naturally. These low hormone levels usually suggest a reduced ovarian reserve, making her success even more remarkable. This outcome highlights the potential of PRP treatment to provide new and effective solutions for women with low ovarian response or those in perimenopause. While IVF remains a well-established and reliable method, laparascopic PRP offers an additional and complementary option for couples looking to enhance their chances of natural conception.
As a specialist in reproductive medicine, my experience, along with my published studies, supports the use of PRP as a means of enhancing natural fertility. This method provides hope and new possibilities for women striving for motherhood under challenging circumstances. Angeliki’s story reinforces confidence in scientific innovations and the perseverance needed to overcome the challenges posed by nature.
It is important to emphasize that this method’s success is not an isolated case. An increasing number of women who had lost hope with conventional treatments are finding new possibilities through this approach. Studies indicate that PRP can significantly improve egg quality and overall ovarian function, making conception possible even at advanced reproductive ages.
In reproductive medicine, every new success is a step toward better understanding and addressing the challenges women face. Angeliki’s journey serves as a powerful reminder that hope should never be abandoned. Through ongoing research and the application of pioneering techniques, we can offer solutions to couples struggling with infertility, giving them the chance to experience the joy of family.
With these advancements, the future of reproductive medicine looks promising, emphasizing personalized treatments and continuous progress to support individuals wishing to start a family. While IVF remains a vital option, new methods like PRP and innovative procedures of its application, like laparascopic PRP, provide additional opportunities and greater chances for success in reproductive medicine.
Aggeliki, full of happiness, expresses joy and satisfaction in her following words: “It was 2023, on the day of Saint Demetrios, when we received yet another negative beta-hCG result. My husband and I agreed to stop all attempts because it seemed futile, and after so many failed IVF cycles, we no longer had the emotional strength to continue.
The phone rang—it was our doctor, Dr Pantos. He was also very saddened by the news. We informed him of our decision, and after a few seconds of silence, he told us that he completely understood but wanted us to consider another suggestion. He mentioned a new PRP method performed laparoscopically, which he had already successfully applied to some women in the same situation as mine—women with low ovarian reserve. We told him that although we had tried PRP twice transvaginally without success, we trusted him and would go ahead with the procedure. He was pleased and added that this new method, due to its approach, allowed better access to the ovaries.
The following week, on November 3rd, I underwent the procedure, and at the same time, he discovered and removed endometriosis. Over the next few months, my cycle was monitored through ultrasounds and blood tests. On March 4th, we found that my AMH had increased from 0.017 to 0.11. Then, on April 1st, we received a positive beta-hCG result from a natural conception. And on December 4th, thanks to the faith and perseverance of our doctor, Mr. Pantos, as well as his team—especially the midwife, Mrs. Stefanidou—we held our little miracle in our arms.”