The rapid development and evolution of the sciences have improved the quality of life and contributed to the increase in human life expectancy. The goal of the scientific community is no longer solely longevity but also well-being.
Senolytic drugs eliminate aging cells through senolysis, such as polyphenols found in various fruits and vegetables, which can extend life expectancy by 30%, enhancing the production of the protective protein α-Klotho.
Inflammation plays a central role in aging, as it is associated with diseases such as autoimmune, cardiovascular, metabolic, neurodegenerative disorders, and certain forms of cancer.
The highest average lifespan is observed among the residents of Sardinia, Okinawa, Loma Linda in California, Ikaria, and Nicoya in Costa Rica. Their habits, such as spending constructive time with friends and family and consuming fruits, vegetables, and red wine, form the five Blue Zones of the world.
The oldest people recorded include Frenchwoman Jeanne Louise Calment, who lived 122 years and 164 days, and Maria Branyas Morera, who reached 117 years. These examples serve as a motivation for new research. Meanwhile, the oldest living person is Tomiko Iroka from Japan, currently 116 years old.
The length of telomeres in chromosomal cells is linked to cardiovascular health and biological age. Recently, a self-test has been developed that, using saliva, can determine this parameter, providing insights into an individual’s biological age. This method avoids paradoxical treatments such as plasma transfusions, cryogenics, and monkey testicle transplants as potential elixirs of youth.
The “precision clock” for aging is based on the measurement of 204 blood proteins. This proteomic clock is the most comprehensive developed to date, capable of predicting the risk of developing 18 chronic diseases that reduce life quality and expectancy, as well as the risk of premature death.
A second “proteomic clock,” utilizing only 20 proteins indicative of the organism’s biological state, achieved a 95% accuracy rate in predicting biological condition compared to the larger model of 204 proteins. It revealed all aging-related characteristics across 18 different chronic diseases and premature death.
“Zombie cells” accumulate in the body over time, releasing toxic substances that cause inflammation. These cells can no longer replicate and eventually undergo apoptosis (cell death).
The combined administration of a targeted senolytic drug with chemotherapy is estimated to prevent disease recurrence.
The Blueprint Project aims to reduce and reverse biological aging. A biosynthetic clock has been developed to prevent cells from reaching normal levels of deterioration and aging through cellular reprogramming. This innovation aspires to extend life to at least 120 years with well-being, leveraging regenerative medicine, nanotechnology, and artificial intelligence.
Konstantinos Kouskoukis
Professor of Dermatology – Lawyer
B’ Vice President GDHI
President Hellenic Academy of Thermal Medicine
President World Academy of Chinese & Complimentary Medicine